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Shalin Mehta

Graduate Student, NUS Graduate School for Integrative Sciences & Engineering (NGS)

Optical Bioimaging Lab,

Div. of Bioengineering, National University of Singapore, Block-E3A, #7-10, 7 Engineering Drive 1, Singapore 117574.

Phone: (+65) 90694182.

email: shalin (dot) mehta (at) gmail (dot) com

Career profile at LinkedIn

I am a PhD student at National University of Singapore (NUS) researching optical imaging methods that allow measurement of specimen morphology without label. I am excited about modeling of image formation (forward problem of imaging) in systems that use large illumination apertures, subsequent retrieval of specimen morphology from the images (inverse problem of imaging), and applications. These phase imaging methods are particularly applicable to study of fast cellular processes such as mitosis (cell division). I am advised by Prof. Colin Sheppard and collaborate with biologists, particularly at Liver Cancer Functional Genomics Lab of Prof. Caroline Lee.

Publications:

Following is the published/presented work with links in reverse chronological order.

Peer-reviewed journal

  • Shalin. B Mehta and Colin. J.R Sheppard, “Using the phase-space imager to analyze partially coherent imaging systems: brightfield, phase-contrast, differential interference contrast, differential phase contrast, and spiral phase contrast,” Journal of Modern Optics, To appear (2010).
  • Shalin. B Mehta and Colin. J.R Sheppard, “Phase-space representation of partially coherent imaging systems using the Cohen class distribution”, Optics Letters, vol. 35, no. 3 (2010), pp. 348-350. [PDF]
  • Shalin. B Mehta and Colin. J.R Sheppard, “Quantitative phase-gradient imaging at high resolution with asymmetric illumination-based differential phase contrast,” Optics Letters, vol. 34, no. 13 (2009), pp. 1924-1926. [PDF]

  • Shalin B. Mehta and Colin J.R. Sheppard, “Partially coherent image formation in differential interference contrast (DIC) microscope,” Optics Express, vol. 16, no. 24 (2008), pp. 19462-19479. [PDF]

Conference presentations (abstract/paper available)

  • [Upcoming] Shalin B. Mehta and Colin J.R. Sheppard, “Partially coherent image formation in Asymmetric Illumination-based Differential Phase Contrast (AIDPC) and phase-retrieval,” Oral Presentation, Advanced Phase Measurement Methods in Optics and Imaging, Locarno, Switzerland, 17-21 May 2010.
  • [Upcoming] Shalin B. Mehta and Colin J.R. Sheppard, “Elucidating image formation in the partially coherent differential interference contrast (DIC) microscope with a point-specimen,” Oral Presentation, Focus on Microscopy, Shanghai, China, 28-31 March 2010.
  • C. JR. Sheppard, S. S. Kou, and S. B. Mehta, “Quantitative Phase Imaging in Microscopy (invited paper),” Fringe 09, September 2009, pp.50. [PDF]
  • “Transfer Function Analysis of Partially Coherent Phase Imaging Methods and Evaluation for Quantitative Imaging,” Shalin B. Mehta and Colin J. Sheppard, Oral presentation, Frontiers in Optics, October 2009, OSA Technical Digest, p. FMK6.[PDF]
  • “A New Phase-Correlation Based Gradient Registration Approach for Phase-Retrieval with DIC and DPC,” Shalin B. Mehta and Colin J.R. Sheppard, Oral presentation, Signal Recovery and Synthesis, October 2009, OSA Technical Digest, p. SWA4.[PDF]
  • “Linear Phase-Gradient Imaging with Asymmetric Illumination Based Differential Phase Contrast (AIDPC),” Shalin B. Mehta and Colin J.R. Sheppard, Oral presentation, Novel Techniques in Microscopy, April 2009, OSA Technical Digest, p. NTuA5.[PDF]

  • “Quantitative phase retrieval in the partially coherent Differential Interference Contrast (DIC) microscope,” Shalin B. Mehta and Colin J.R. Sheppard, Oral presentation, Focus on Microscopy, April 2009.[PDF]
  • “Full-field phase-gradient contrast methods for label-free quantitative imaging of cellular morphology: AIDPC and DIC,” Shalin B. Mehta and Colin J.R. Sheppard, Poster presentation, Focus on Microscopy, April 2009.[PDF]
  • “Asymmetric illumination based differential phase contrast (AI-DPC) for full-field transmission imaging of phase information in biological specimens,” Shalin B. Mehta and Colin J.R. Sheppard, Oral presentation, Focus on Microscopy, April 2008.[PDF]

Other conference presentations

If something catches your interest, I will be happy to email the slides.

  • [Upcoming] “Quantitative imaging of morphology with partially coherent methods: forward and inverse analysis of DIC and DPC,” Shalin B. Mehta and Colin J.R. Sheppard, Poster presentation, Novel Approaches to Bioimaging II, Janelia Farm Research Campus, Virginia, May 2 – 5, 2010.
  • “Full-field phase-gradient contrast methods for label-free quantitative imaging of cellular morphology: AIDPC and DIC,” Shalin B. Mehta and Colin J.R. Sheppard, Oral presentation, 1st NGS (NUS graduate school for integrative sciences & engineering) Symposium, Singapore, Feb 2009.

  • “Quantitative imaging with Differential Interference Contrast (DIC) microscope – Role of coherence of illumination,” Shalin B. Mehta and Colin J.R. Sheppard, Oral presentation, GPBE/NUS- Tohoku Graduate Student Conference in Bioengineering, Singapore, Dec 2008.
  • “Phase imaging with oblique illumination,” Shalin B. Mehta and Colin J.R. Sheppard, Oral presentation, 10th Optics Within Life Sciences Conference, Singapore, Jul. 2008.
  • “Comparison of phase imaging methods based on optical processing at back focal plane,” Shalin B. Mehta, Colin J.R. Sheppard, and Caroline G.L. Lee, Invited presentation, Bioengineering seminar series, Singapore, Feb. 08.
  • “Quantitative 3D and time-lapse imaging to investigate causative role of FAT10 in mitotic dysregulation,” Shalin B. Mehta, Jianwei Ren, Caroline G.L. Lee, and Colin J.R. Sheppard, Oral presentation, Graduate Student Symposium in Biological and Chemical Engineering, Singapore, Sep. 2007.
  • “Towards 3D quantification of hESC cultures by confocal microscopy,” Shalin B. Mehta, Lucky A.K. Kosasih, Andre Choo, Steve Oh, Ivan Reading, and Colin J.R. Sheppard, 5th ISSCR Annual Meeting, Cairns, Australia, Jun. 2007.

Professional participation:

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